TMA, TMAO and diseases

therefore, the body of trimethylaminuria patients frees TMA (volatile), leading to a rotten-fish odor. This (inborn or acquired) disease is highly psychologically and socially perturbating. As an inborn disease, it is believed to be a rare disease (meaning 1 of 40.000 people in UK) : this prevalence varies among populations. Also, transient trimethylaminuria is frequently reported: it results from transient deficiency of the liver FMO3 enzyme (notably during hormonal changes in women).