TMAO
How it works...
In fact, rapidly said, our diet contains several precursors of plasma TMAO... Several N-methyl compounds contained in the food (lecithin, L-carnitine,...) can reach the gut; they are then metabolized into TMA (trimethylamine) by gut microbes. As nobody has the same gut microbiota, the efficiency to generate TMA is variable among people and depends on the amount and nature of TMA-generating diet. Newly synthesised TMA is next absorbed and goes to the liver, where it is oxidized into TMAO (TMA oxide).
Next, pTMAO reaches the plasma where it has various deleterious action, before being excreted by urine.
A more detailed description of this phenomenon can be found on this site.