TMA, TMAO and diseases
Trimethylaminuria - Fish-odor syndrome
therefore, the body of trimethylaminuria patients frees TMA (volatile), leading to a rotten-fish odor. This (inborn or acquired) disease is highly psychologically and socially perturbating. As an inborn disease, it is believed to be a rare disease (meaning 1 of 40.000 people in UK) : this prevalence varies among populations. Also, transient trimethylaminuria is frequently reported: it results from transient deficiency of the liver FMO3 enzyme (notably during hormonal changes in women).
therefore, the body of trimethylaminuria patients frees TMA (volatile), leading to a rotten-fish odor. This (inborn or acquired) disease is highly psychologically and socially perturbating. As an inborn disease, it is believed to be a rare disease (meaning 1 of 40.000 people in UK) : this prevalence varies among populations. Also, transient trimethylaminuria is frequently reported: it results from transient deficiency of the liver FMO3 enzyme (notably during hormonal changes in women).
TMA, the rotten fish odour
TMA is the molecule which is naturally occuring from rotten fishes: Typically, seafoods contain large amounts of TMAO. When fishes are dead, some microbes perform their decomposition leading to rotten fishes, with their characteristical and very unpleasant odor (to which humans are very sensitive): this is due to TMA resulting from the enzymatic conversion of TMAO by rotting microbes.
TMA is the molecule which is naturally occuring from rotten fishes: Typically, seafoods contain large amounts of TMAO. When fishes are dead, some microbes perform their decomposition leading to rotten fishes, with their characteristical and very unpleasant odor (to which humans are very sensitive): this is due to TMA resulting from the enzymatic conversion of TMAO by rotting microbes.