Rationale of the use of Archaea

to deplete TMA in the intestine / pTMAO in plasma

There are various (hypothetical) targets to avoid either TMAO in plasma / TMA in intestine. Most of them are either very complex to develop, unrealistic or dangerous. For example, N-methyl coumponds supplied by the diet are needed for the correct physiolog and their deficiency would lead to severe consequences. Also,antibiotics use could be an efficient way to avoid bacteria / bacteria converting N-methyl compounds in the gut, but the consequences of a long-term therapy by antibiotics would be also very dangerous. Also, acting on the hepatic (human) FMO3 enzyme activity would avoid TMAO in plasma, but would lead to TMA in blood / body fluids, like Trimethylaminuria patients, which is not conceivable.